SCHEDULED MAINTENANCE
A practical and efficient synthesis of functionalized 3-hydroxypyrrolidinones through a domino aza-Michael/aldol reaction of α-ketoamides with chalcone has been realized. The domino reaction proceeded smoothly with NHC as a catalyst, affording 3-hydroxypyrrolidinones in good to excellent yields with excellent functional group tolerance.
Y. Zhu and C. Cai, New J. Chem., 2015, 39, 5104 DOI: 10.1039/C4NJ02420F
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