A highly enantioselective Michael reaction between α,β-unsaturated ketones and malonic acid half-thioesters†
Abstract
We disclose herein an efficient enantioselective organocatalytic Michael reaction between α,β-unsaturated ketones and malonic acid half thioesters (MAHTs). The reactions are catalyzed by a primary amine to generate Michael addition products in good to excellent yields (62–87%) with high to excellent enantioselectivities (80–98%).