Jump to main content
Jump to site search

Issue 15, 2015
Previous Article Next Article

An acoustofluidic sputum liquefier

Author affiliations


We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min−1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Graphical abstract: An acoustofluidic sputum liquefier

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 May 2015, accepted on 08 Jun 2015 and first published on 17 Jun 2015

Article type: Paper
DOI: 10.1039/C5LC00539F
Lab Chip, 2015,15, 3125-3131

  •   Request permissions

    An acoustofluidic sputum liquefier

    P. Huang, L. Ren, N. Nama, S. Li, P. Li, X. Yao, R. A. Cuento, C. Wei, Y. Chen, Y. Xie, A. A. Nawaz, Y. G. Alevy, M. J. Holtzman, J. P. McCoy, S. J. Levine and T. J. Huang, Lab Chip, 2015, 15, 3125
    DOI: 10.1039/C5LC00539F

Search articles by author