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Issue 15, 2015
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An acoustofluidic sputum liquefier

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We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min−1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Graphical abstract: An acoustofluidic sputum liquefier

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Article information

12 May 2015
08 Jun 2015
First published
17 Jun 2015

Lab Chip, 2015,15, 3125-3131
Article type

An acoustofluidic sputum liquefier

P. Huang, L. Ren, N. Nama, S. Li, P. Li, X. Yao, R. A. Cuento, C. Wei, Y. Chen, Y. Xie, A. A. Nawaz, Y. G. Alevy, M. J. Holtzman, J. P. McCoy, S. J. Levine and T. J. Huang, Lab Chip, 2015, 15, 3125
DOI: 10.1039/C5LC00539F

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