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Issue 15, 2015
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An acoustofluidic sputum liquefier

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Abstract

We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min−1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Graphical abstract: An acoustofluidic sputum liquefier

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Publication details

The article was received on 12 May 2015, accepted on 08 Jun 2015 and first published on 17 Jun 2015


Article type: Paper
DOI: 10.1039/C5LC00539F
Lab Chip, 2015,15, 3125-3131

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    An acoustofluidic sputum liquefier

    P. Huang, L. Ren, N. Nama, S. Li, P. Li, X. Yao, R. A. Cuento, C. Wei, Y. Chen, Y. Xie, A. A. Nawaz, Y. G. Alevy, M. J. Holtzman, J. P. McCoy, S. J. Levine and T. J. Huang, Lab Chip, 2015, 15, 3125
    DOI: 10.1039/C5LC00539F

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