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Issue 7, 2015
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Copper-catalyzed hydroxylation of aryl halides: efficient synthesis of phenols, alkyl aryl ethers and benzofuran derivatives in neat water

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Abstract

A thorough study of environmentally friendly hydroxylation of aryl halides is presented. The best protocol consists of hydroxylation of different aryl bromides and electron-deficient aryl chlorides by water solution of tetrabutylammonium hydroxide catalyzed by Cu2O/4,7-dihydroxy-1,10-phenanthroline. Various phenol derivatives can be obtained in excellent selectivity and great functional group tolerance. This methodology also provides a direct pathway for the formation of alkyl aryl ethers and benzofuran derivatives in a one-pot tandem reaction.

Graphical abstract: Copper-catalyzed hydroxylation of aryl halides: efficient synthesis of phenols, alkyl aryl ethers and benzofuran derivatives in neat water

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The article was received on 23 Apr 2015, accepted on 15 May 2015 and first published on 18 May 2015


Article type: Paper
DOI: 10.1039/C5GC00871A
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Citation: Green Chem., 2015,17, 3910-3915
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    Copper-catalyzed hydroxylation of aryl halides: efficient synthesis of phenols, alkyl aryl ethers and benzofuran derivatives in neat water

    Y. Wang, C. Zhou and R. Wang, Green Chem., 2015, 17, 3910
    DOI: 10.1039/C5GC00871A

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