trans-Platinum(ii) complex of 3-aminoflavone – synthesis, X-ray crystal structure and biological activities in vitro

Abstract

This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)₂Cl₂; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)₂Cl₂ is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)₂Cl₂ may have a different antitumour specificity from that of cisplatin.