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Issue 84, 2015
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The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

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Abstract

A highly efficient Cu(II)-catalyzed enantioselective inverse-electron-demand aza-Diels–Alder reaction of in situ formed azoalkenes with enol ethers is reported. This methodology provides a facile entry to biologically important and enantioenriched tetrahydropyridazine derivatives in generally good yield (up to 95% yield) with good to excellent enantioselectivity (up to 94% ee).

Graphical abstract: The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

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Publication details

The article was received on 02 Aug 2015, accepted on 25 Aug 2015 and first published on 25 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC06465A
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Citation: Chem. Commun., 2015,51, 15374-15377
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    The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

    L. Wei and C. Wang, Chem. Commun., 2015, 51, 15374
    DOI: 10.1039/C5CC06465A

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