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Issue 84, 2015
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The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

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Abstract

A highly efficient Cu(II)-catalyzed enantioselective inverse-electron-demand aza-Diels–Alder reaction of in situ formed azoalkenes with enol ethers is reported. This methodology provides a facile entry to biologically important and enantioenriched tetrahydropyridazine derivatives in generally good yield (up to 95% yield) with good to excellent enantioselectivity (up to 94% ee).

Graphical abstract: The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

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Supplementary files

Article information


Submitted
02 Aug 2015
Accepted
25 Aug 2015
First published
25 Aug 2015

Chem. Commun., 2015,51, 15374-15377
Article type
Communication
Author version available

The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

L. Wei and C. Wang, Chem. Commun., 2015, 51, 15374
DOI: 10.1039/C5CC06465A

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