Issue 84, 2015

Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

Abstract

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva–King reaction, and a copper-catalyzed cyanation.

Graphical abstract: Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

Supplementary files

Article information

Article type
Communication
Submitted
14 Jul 2015
Accepted
21 Aug 2015
First published
21 Aug 2015

Chem. Commun., 2015,51, 15378-15381

Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

Q. Wen, P. Lu and Y. Wang, Chem. Commun., 2015, 51, 15378 DOI: 10.1039/C5CC05821J

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