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Issue 77, 2015
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Biomimetic synthesis of Tramadol

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Abstract

Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product–precursor relationship has been probed by 13C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.

Graphical abstract: Biomimetic synthesis of Tramadol

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Article information


Submitted
17 Jul 2015
Accepted
05 Aug 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 14451-14453
Article type
Communication
Author version available

Biomimetic synthesis of Tramadol

F. Lecerf-Schmidt, R. Haudecoeur, B. Peres, M. M. Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J. Wolfender, M. De Waard, R. J. Robins and A. Boumendjel, Chem. Commun., 2015, 51, 14451
DOI: 10.1039/C5CC05948H

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