Issue 77, 2015
From the journal:

Chemical Communications

Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing†

Michael T. Cook,a   Sarah L. Smithb  and  Vitaliy V. Khutoryanskiy*b  

* Corresponding authors

a Department of Pharmacy, University of Hertfordshire, Hatfield, UK

b School of Pharmacy, University of Reading, Reading, UK
E-mail: v.khutoryanskiy@reading.ac.uk
Tel: +44 (0) 118 378 6119

Abstract

Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion.

Graphical abstract: Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

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Article information

DOI
https://doi.org/10.1039/C5CC02428E
Article type
Communication
Submitted
25 Mar 2015
Accepted
21 Jul 2015
First published
21 Jul 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 14447-14450

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Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

M. T. Cook, S. L. Smith and V. V. Khutoryanskiy, Chem. Commun., 2015, 51, 14447 DOI: 10.1039/C5CC02428E

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