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Issue 80, 2015
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An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C–C bond formation

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Abstract

Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step.

Graphical abstract: An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C–C bond formation

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Supplementary files

Article information


Submitted
13 Jul 2015
Accepted
17 Aug 2015
First published
17 Aug 2015

Chem. Commun., 2015,51, 14866-14868
Article type
Communication
Author version available

An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C–C bond formation

D. Caprioglio and S. P. Fletcher, Chem. Commun., 2015, 51, 14866
DOI: 10.1039/C5CC05805H

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