Issue 77, 2015

Enantio- and diastereoselective synthesis of γ-amino alcohols

Abstract

The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N-PMP-protected γ-amino alcohols from the corresponding ketones. The anti-products were obtained through Ir-catalyzed asymmetric transfer hydrogenation, the syn-products via Rh-catalyzed asymmetric hydrogenation.

Graphical abstract: Enantio- and diastereoselective synthesis of γ-amino alcohols

Supplementary files

Article information

Article type
Communication
Submitted
30 May 2015
Accepted
05 Aug 2015
First published
05 Aug 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 14462-14464

Enantio- and diastereoselective synthesis of γ-amino alcohols

J. M. M. Verkade, P. J. L. M. Quaedflieg, G. K. M. Verzijl, L. Lefort, F. L. van Delft, J. G. de Vries and F. P. J. T. Rutjes, Chem. Commun., 2015, 51, 14462 DOI: 10.1039/C5CC04445F

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