Issue 77, 2015

Photocatalytic oxidation of TMB with the double stranded DNA–SYBR Green I complex for label-free and universal colorimetric bioassay

Abstract

We report here the newly discovered photocatalytic activity of the dsDNA–SYBR Green I (SG) complex, which can catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) under light irradiation corresponding to the excitation of the dsDNA–SG complex. The most appealing feature of the photocatalytic system here is that it can be obtained using random DNA sequences that can form a duplex. Considering the universality of the photooxidase, a label-free and universal platform was proposed for highly sensitive visual bioassays.

Graphical abstract: Photocatalytic oxidation of TMB with the double stranded DNA–SYBR Green I complex for label-free and universal colorimetric bioassay

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2015
Accepted
07 Aug 2015
First published
07 Aug 2015

Chem. Commun., 2015,51, 14465-14468

Author version available

Photocatalytic oxidation of TMB with the double stranded DNA–SYBR Green I complex for label-free and universal colorimetric bioassay

X. Zhang, C. Huang, S. Xu, J. Chen, Y. Zeng, P. Wu and X. Hou, Chem. Commun., 2015, 51, 14465 DOI: 10.1039/C5CC06105A

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