Issue 64, 2015

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Abstract

A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

Graphical abstract: Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

Supplementary files

Article information

Article type
Communication
Submitted
12 May 2015
Accepted
06 Jul 2015
First published
06 Jul 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 12807-12810

Author version available

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

A. J. Paterson, S. St John-Campbell, M. F. Mahon, N. J. Press and C. G. Frost, Chem. Commun., 2015, 51, 12807 DOI: 10.1039/C5CC03951G

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