Issue 62, 2015

Facile synthesis of 1-trifluoromethylalkenes via the decarboxylation of α-trifluoromethyl-β-lactones

Abstract

DCC-mediated cyclodehydration of α-trifluoromethyl-β-hydroxy acids provides α-trifluoromethylated β-lactone intermediates, without loss of stereoselectivity. These lactones undergo facile decarboxylation providing a simple route to obtain both alkyl and aryl trifluoromethylated alkenes in excellent yields and stereoselectivity.

Graphical abstract: Facile synthesis of 1-trifluoromethylalkenes via the decarboxylation of α-trifluoromethyl-β-lactones

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2015
Accepted
26 Jun 2015
First published
26 Jun 2015

Chem. Commun., 2015,51, 12388-12390

Facile synthesis of 1-trifluoromethylalkenes via the decarboxylation of α-trifluoromethyl-β-lactones

P. Veeraraghavan Ramachandran and B. Otoo, Chem. Commun., 2015, 51, 12388 DOI: 10.1039/C5CC03230J

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