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Issue 44, 2015
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The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant

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Abstract

Heterogeneously catalyzed synthesis of quinazolinones or quinazolines is reported in this study. An α-MnO2 catalyst is found to be highly active and selective in the oxidative cyclization of anthranilamides or aminobenzylamines with alcohols using TBHP as an oxidant. This protocol exhibits a broad substrate scope, and is operationally simple without an additive.

Graphical abstract: The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant

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Supplementary files

Article information


Submitted
03 Apr 2015
Accepted
28 Apr 2015
First published
28 Apr 2015

Chem. Commun., 2015,51, 9205-9207
Article type
Communication
Author version available

The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant

Z. Zhang, M. Wang, C. Zhang, Z. Zhang, J. Lu and F. Wang, Chem. Commun., 2015, 51, 9205
DOI: 10.1039/C5CC02785C

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