Issue 51, 2015

Lamellar sheet exfoliation of single lipid vesicles by a membrane-active peptide

Abstract

Using total internal fluorescence microscopy, highly parallel measurements of single lipid vesicles unexpectedly reveal that a small fraction of vesicles rupture in multiple discrete steps when destabilized by a membrane-active peptide which is in contrast to classical solubilization models. To account for this surprizing kinetic behaviour, we identified that this vesicle subpopulation consists of multilamellar vesicles, and that the outermost lamella is more susceptible to rupture than unilamellar vesicles of even smaller size. This finding sheds light on the multiple ways in which membrane configuration can influence strain in the bilayer leaflet and contribute to nm-scale membrane curvature sensing.

Graphical abstract: Lamellar sheet exfoliation of single lipid vesicles by a membrane-active peptide

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2015
Accepted
06 May 2015
First published
06 May 2015

Chem. Commun., 2015,51, 10272-10275

Lamellar sheet exfoliation of single lipid vesicles by a membrane-active peptide

S. R. Tabaei and N. J. Cho, Chem. Commun., 2015, 51, 10272 DOI: 10.1039/C5CC02769A

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