Issue 41, 2015
From the journal:

Chemical Communications

A concise formal total synthesis of lactimidomycin†

Wei Lia  and  Gunda I. Georg*a  

* Corresponding authors

a Department of Chemistry, Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, USA
E-mail: Georg@umn.edu
Fax: +1-612-626-6318
Tel: +1-612-626-6320

Abstract

A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene–yne coupling/alkyne reduction tandem reaction.

Graphical abstract: A concise formal total synthesis of lactimidomycin

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Article information

DOI
https://doi.org/10.1039/C5CC02571K
Article type
Communication
Submitted
28 Mar 2015
Accepted
14 Apr 2015
First published
22 Apr 2015

Chem. Commun., 2015,51, 8634-8636

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A concise formal total synthesis of lactimidomycin

W. Li and G. I. Georg, Chem. Commun., 2015, 51, 8634 DOI: 10.1039/C5CC02571K

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