Issue 35, 2015
From the journal:

Chemical Communications

Novel olfactory ligands via terpene synthases†

Sabrina Touchet,a   Keith Chamberlain,b   Christine M. Woodcock,b   David J. Miller,a   Michael A. Birkett,b   John A. Pickett*b  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, UK
E-mail: allemannrk@cardiff.ac.uk

b Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden, Hertfordshire, UK
E-mail: john.pickett@rothamsted.ac.uk

Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Graphical abstract: Novel olfactory ligands via terpene synthases

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Article information

DOI
https://doi.org/10.1039/C5CC01814E
Article type
Communication
Submitted
03 Mar 2015
Accepted
30 Mar 2015
First published
07 Apr 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 7550-7553

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Novel olfactory ligands via terpene synthases

S. Touchet, K. Chamberlain, C. M. Woodcock, D. J. Miller, M. A. Birkett, J. A. Pickett and R. K. Allemann, Chem. Commun., 2015, 51, 7550 DOI: 10.1039/C5CC01814E

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