Issue 35, 2015

Novel olfactory ligands via terpene synthases


A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Graphical abstract: Novel olfactory ligands via terpene synthases

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Article information

Article type
03 Mar 2015
30 Mar 2015
First published
07 Apr 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 7550-7553

Author version available

Novel olfactory ligands via terpene synthases

S. Touchet, K. Chamberlain, C. M. Woodcock, D. J. Miller, M. A. Birkett, J. A. Pickett and R. K. Allemann, Chem. Commun., 2015, 51, 7550 DOI: 10.1039/C5CC01814E

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