Issue 27, 2015

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.

Graphical abstract: A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Supplementary files

Article information

Article type
Communication
Submitted
09 Feb 2015
Accepted
21 Feb 2015
First published
26 Feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 6018-6021

Author version available

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen, J. A. Frank, N. R. Johnston, R. K. Mitchell, K. Šmid, P. Marchetti, M. Bugliani, G. A. Rutter, D. Trauner and D. J. Hodson, Chem. Commun., 2015, 51, 6018 DOI: 10.1039/C5CC01224D

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