Issue 26, 2015

Cobalt-catalyzed asymmetric hydroboration of aryl ketones with pinacolborane

Abstract

The highly enantioselective cobalt-catalyzed hydroboration reaction of aryl ketones with HBpin was developed using iminopyridine oxazoline ligands. Halides, amines, ethers, sulfides, esters and amides are well tolerated under the mild reaction conditions, demonstrating its synthetic advantage. Substituted diaryl ketones could also be hydroborated with high enantioselectivity.

Graphical abstract: Cobalt-catalyzed asymmetric hydroboration of aryl ketones with pinacolborane

Supplementary files

Article information

Article type
Communication
Submitted
05 Feb 2015
Accepted
19 Feb 2015
First published
20 Feb 2015

Chem. Commun., 2015,51, 5725-5727

Author version available

Cobalt-catalyzed asymmetric hydroboration of aryl ketones with pinacolborane

J. Guo, J. Chen and Z. Lu, Chem. Commun., 2015, 51, 5725 DOI: 10.1039/C5CC01084E

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