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Issue 26, 2015
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An oral redox-sensitive self-immolating prodrug strategy

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Abstract

We report a novel oral prodrug approach where a solubilizing polymer conjugated to the drug is designed to be released by the action of an exogenously administered agent in the intestine. A redox-sensitive self-immolating design was implemented, and the reconversion kinetics were studied for three reducible prodrugs.

Graphical abstract: An oral redox-sensitive self-immolating prodrug strategy

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Article information


Submitted
15 Jan 2015
Accepted
20 Feb 2015
First published
20 Feb 2015

Chem. Commun., 2015,51, 5721-5724
Article type
Communication

An oral redox-sensitive self-immolating prodrug strategy

T. Sun, A. Morger, B. Castagner and J. Leroux, Chem. Commun., 2015, 51, 5721
DOI: 10.1039/C5CC00405E

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