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Issue 32, 2015

i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid

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Abstract

Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution.

Graphical abstract: i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid

Supplementary files

Article information


Submitted
30 Jan 2015
Accepted
23 Feb 2015
First published
25 Feb 2015

Chem. Commun., 2015,51, 6909-6912
Article type
Communication
Author version available

i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid

H. Tateishi-Karimata, M. Nakano, S. Pramanik, S. Tanaka and N. Sugimoto, Chem. Commun., 2015, 51, 6909 DOI: 10.1039/C5CC00666J

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