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Issue 23, 2015
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Iron-catalyzed tandem cyclization of olefinic dicarbonyl compounds with benzylic Csp3–H bonds for the synthesis of dihydrofurans

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Abstract

A novel iron-catalyzed radical cyclization of olefinic dicarbonyl compounds with benzyl hydrocarbons has been developed. This protocol provides ready access to a variety of dihydrofurans containing a quaternary carbon center in moderate to good yields. Furthermore, this reaction could also be further expanded to other types of substrates containing unactivated Csp3–H bonds, such as ethers and alkanes.

Graphical abstract: Iron-catalyzed tandem cyclization of olefinic dicarbonyl compounds with benzylic Csp3–H bonds for the synthesis of dihydrofurans

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Publication details

The article was received on 16 Jan 2015, accepted on 10 Feb 2015 and first published on 10 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00426H
Chem. Commun., 2015,51, 4803-4806

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    Iron-catalyzed tandem cyclization of olefinic dicarbonyl compounds with benzylic Csp3–H bonds for the synthesis of dihydrofurans

    L. Guo, S. Wang, X. Duan and S. Zhou, Chem. Commun., 2015, 51, 4803
    DOI: 10.1039/C5CC00426H

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