Issue 8, 2015

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Abstract

Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Graphical abstract: Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2014
Accepted
02 Dec 2014
First published
03 Dec 2014

Chem. Commun., 2015,51, 1532-1534

Author version available

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

G. Sreenilayam and R. Fasan, Chem. Commun., 2015, 51, 1532 DOI: 10.1039/C4CC08753D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements