Near infrared activation of an anticancer PtIV complex by Tm-doped upconversion nanoparticles

Emmanuel Ruggiero; Javier Hernández-Gil; Juan C. Mareque-Rivas; Luca Salassa

doi:10.1039/C4CC07960D

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Near infrared activation of an anticancer Pt^IV complex by Tm-doped upconversion nanoparticles†

Emmanuel Ruggiero,^a Javier Hernández-Gil,^a Juan C. Mareque-Rivas^ab and Luca Salassa*^a

Author affiliations

* Corresponding authors

^a CIC biomaGUNE, Paseo de Miramón 182, Donostia, Euskadi, Spain
E-mail: lsalassa@cicbiomagune.es

^b Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Euskadi, Spain

Abstract

The Pt^IV complex cis,cis,trans-[Pt(NH₃)₂(Cl)₂(O₂CCH₂CH₂CO₂H)₂] is photoactivated by near infrared light (980 nm) using NaYF₄:Yb³⁺/Tm³⁺@NaYF₄ core–shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH₂ affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing Pt^II species upon NIR light excitation.

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Correction: Near infrared activation of an anticancer PtIV complex by Tm-doped u…

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Article information

DOI: https://doi.org/10.1039/C4CC07960D
Article type: Communication
Submitted: 08 Oct 2014
Accepted: 08 Dec 2014
First published: 11 Dec 2014

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Chem. Commun., 2015,51, 2091-2094

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Near infrared activation of an anticancer Pt^IV complex by Tm-doped upconversion nanoparticles

E. Ruggiero, J. Hernández-Gil, J. C. Mareque-Rivas and L. Salassa, Chem. Commun., 2015, 51, 2091 DOI: 10.1039/C4CC07960D

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