An l-lysine derived organogelator-based stationary phase for mixed-mode liquid chromatography

Abstract

An L-lysine-based, urea containing organogelator-modified silica stationary phase, with ordered functional groups, was applied for the separation of chiral analytes and polar analytes. The molecularly oriented functional group arrangement in the stationary phase enhanced the chromatographic performance thus making the separation of chiral and polar analytes possible. Chiral separation using gelator–silica hybrid particles is reported for the first time.