Jump to main content
Jump to site search

Issue 1, 2015
Previous Article Next Article

Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

Author affiliations

Abstract

Nontoxic and acid-degradable cross-linked polymeric vesicles as efficient nanocarriers for the delivery of platinum drugs are reported. Well-defined linear-brush diblock copolymers were synthesized via a robust ring opening metathesis polymerization technique and self-assembled in a selective solvent to form polymeric vesicles with bilayer structure. Vesicles were subsequently cross-linked using acid-degradable diamino ketal cross-linkers and the anticancer drug cis-platin was conjugated to the vesicles with a high loading content (17.6%) through the formation of stable chelate ring structure. This acid-degradable linker leads to a faster drug release in saline under acidic conditions (pH = 5.5) such as those encountered in the late endosome compared to physiological pH (pH = 7.4). Cancer cells tended to readily internalize the vesicles and dose–response cytotoxicity studies suggested that the drug-loaded cross-linked vesicles were more efficient in delivering the platinum drug into cancer cells compared to internalization of the free drug. Additionally, polymer vesicles prior to platinum conjugation were nontoxic towards cancer cells.

Graphical abstract: Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Aug 2014, accepted on 15 Sep 2014 and first published on 16 Sep 2014


Article type: Paper
DOI: 10.1039/C4PY01123F
Author version
available:
Download author version (PDF)
Polym. Chem., 2015,6, 35-43
  • Open access: Creative Commons BY license
  •   Request permissions

    Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

    Q. Fu, J. Xu, K. Ladewig, T. M. A. Henderson and G. G. Qiao, Polym. Chem., 2015, 6, 35
    DOI: 10.1039/C4PY01123F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements