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Issue 24, 2015
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Iodine promoted α-hydroxylation of ketones

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A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydroxylation of aryl ketones using a sub-stoichiometric amount of molecular iodine.

Graphical abstract: Iodine promoted α-hydroxylation of ketones

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Supplementary files

Article information

06 Apr 2015
11 May 2015
First published
11 May 2015

Org. Biomol. Chem., 2015,13, 6749-6753
Article type
Author version available

Iodine promoted α-hydroxylation of ketones

Y. Siddaraju and K. R. Prabhu, Org. Biomol. Chem., 2015, 13, 6749
DOI: 10.1039/C5OB00684H

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