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Issue 21, 2015
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Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

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Abstract

Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.

Graphical abstract: Synthesis of multiply substituted 1,6-dihydropyridines through Cu(i)-catalyzed 6-endo cyclization

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Publication details

The article was received on 21 Feb 2015, accepted on 20 Apr 2015 and first published on 21 Apr 2015


Article type: Paper
DOI: 10.1039/C5OB00356C
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Org. Biomol. Chem., 2015,13, 5955-5963

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    Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

    H. Mizoguchi, R. Watanabe, S. Minami, H. Oikawa and H. Oguri, Org. Biomol. Chem., 2015, 13, 5955
    DOI: 10.1039/C5OB00356C

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