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Issue 10, 2015
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Transition-metal-free C–H oxidative activation: persulfate-promoted selective benzylic mono- and difluorination

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Abstract

An operationally simple and selective method for the direct conversion of benzylic C–H to C–F to obtain mono- and difluoromethylated arenes using Selectfluor™ as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C–F bond formation without the aid of transition metal catalysts.

Graphical abstract: Transition-metal-free C–H oxidative activation: persulfate-promoted selective benzylic mono- and difluorination

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Article information


Submitted
18 Nov 2014
Accepted
16 Jan 2015
First published
16 Jan 2015

Org. Biomol. Chem., 2015,13, 2890-2894
Article type
Communication
Author version available

Transition-metal-free C–H oxidative activation: persulfate-promoted selective benzylic mono- and difluorination

J. Ma, W. Yi, G. Lu and C. Cai, Org. Biomol. Chem., 2015, 13, 2890
DOI: 10.1039/C4OB02418D

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