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Issue 21, 2015
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Can graphene quantum dots cause DNA damage in cells?

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Abstract

Graphene quantum dots (GQDs) have attracted tremendous attention for biological applications. We report the first study on cytotoxicity and genotoxicity of GQDs to fibroblast cell lines (NIH-3T3 cells). The NIH-3T3 cells treated with GQDs at dosages over 50 μg mL−1 showed no significant cytotoxicity. However, the GQD-treated NIH-3T3 cells exhibited an increased expression of proteins (p53, Rad 51, and OGG1) related to DNA damage compared with untreated cells, indicating the DNA damage caused by GQDs. The GQD-induced release of reactive oxygen species (ROS) was demonstrated to be responsible for the observed DNA damage. These findings should have important implications for future applications of GQDs in biological systems.

Graphical abstract: Can graphene quantum dots cause DNA damage in cells?

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Supplementary files

Article information


Submitted
17 Mar 2015
Accepted
21 Apr 2015
First published
27 Apr 2015

Nanoscale, 2015,7, 9894-9901
Article type
Paper

Can graphene quantum dots cause DNA damage in cells?

D. Wang, L. Zhu, J. Chen and L. Dai, Nanoscale, 2015, 7, 9894
DOI: 10.1039/C5NR01734C

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