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Issue 3, 2015
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Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins

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Abstract

Covering: up to August 2014

From a small group of exotic compounds isolated only two decades ago, Cyclic Imine (CI) toxins have become a major class of marine toxins with global distribution. Their distinct chemical structure, biological mechanism of action, and intricate chemistry ensures that CI toxins will continue to be the subject of fascinating fundamental studies in the broad fields of chemistry, chemical biology, and toxicology. The worldwide occurrence of potent CI toxins in marine environments, their accumulation in shellfish, and chemical stability are important considerations in assessing risk factors for human health. This review article aims to provide an account of chemistry, biology, and toxicology of CI toxins from their discovery to the present day.

Graphical abstract: Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins

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Publication details

The article was received on 23 Jun 2014 and first published on 22 Oct 2014


Article type: Review Article
DOI: 10.1039/C4NP00089G
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Nat. Prod. Rep., 2015,32, 411-435

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    Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins

    C. E. Stivala, E. Benoit, R. Aráoz, D. Servent, A. Novikov, J. Molgó and A. Zakarian, Nat. Prod. Rep., 2015, 32, 411
    DOI: 10.1039/C4NP00089G

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