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Issue 8, 2015
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Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

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Abstract

The first example of glycine-catalyzed direct domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in aqueous medium is described, giving products in excellent yields and moderate to excellent diastereoselectivities. This approach provides a highly efficient and environmentally benign access to cyano-substituted 2,7-dioxabicyclo[3.2.1]octane.

Graphical abstract: Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

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Article information


Submitted
29 Apr 2015
Accepted
04 Jun 2015
First published
04 Jun 2015

Green Chem., 2015,17, 4234-4238
Article type
Paper
Author version available

Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

O. V. Ershov, M. Yu. Ievlev, V. A. Tafeenko and O. E. Nasakin, Green Chem., 2015, 17, 4234
DOI: 10.1039/C5GC00909J

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