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Issue 15, 2015
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Metal complexes of curcumin – synthetic strategies, structures and medicinal applications

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Abstract

This Tutorial Review presents an overview on the synthesis, characterization and applications of metal complexes containing curcumin (=1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its derivatives as ligands. Innovative synthetic strategies leading to soluble and crystallizable metal curcumin complexes are outlined in detail. Special emphasis is placed on the highly promising and exciting medicinal applications of metal curcumin complexes, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alzheimer's disease activity, and antioxidative/neuroprotective effects. Overall, this Tutorial Review provides the first general overview of this emerging and rapidly expanding field of interdisciplinary research.

Graphical abstract: Metal complexes of curcumin – synthetic strategies, structures and medicinal applications

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Publication details

The article was received on 30 Jan 2015 and first published on 12 May 2015


Article type: Tutorial Review
DOI: 10.1039/C5CS00088B
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Chem. Soc. Rev., 2015,44, 4986-5002
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    Metal complexes of curcumin – synthetic strategies, structures and medicinal applications

    S. Wanninger, V. Lorenz, A. Subhan and F. T. Edelmann, Chem. Soc. Rev., 2015, 44, 4986
    DOI: 10.1039/C5CS00088B

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