Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

There will be scheduled maintenance work beginning on Saturday 15th June 2019 at 8:30 am through to Sunday 16th June 2019 at 11:30 pm (BST).

During this time our website may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 19, 2015
Previous Article Next Article

Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

Author affiliations

Abstract

Polyelectrolyte multilayers serve as effective reservoirs for bioactive molecules which are stored and released from the multilayers for cellular applications. However, control over the release without significantly affecting the multilayers and biomolecules is still a challenge. On the other hand, externally stimulated release would make the multilayers promising for the development of stimuli-sensitive planar carriers with release performance switched on demand. In this study soft composite films are designed by coating hyaluronic acid/poly-L-lysine (HA/PLL) multilayers with temperature responsive poly(N-isopropylacrylamide) (PNIPAM) microgels. Microgels are flattened and immersed into the multilayers to maximize the number of contacts with the surrounding polyelectrolytes (HA and PLL). The microgel coating serves as an efficient switchable barrier for the PLL transport into the multilayers. PLL diffusion into the film is significantly hindered at room temperature but is dramatically enhanced at 40 °C above the volume phase transition temperature (VPTT) of PNIPAM at 32 °C associated with microgel shrinkage. Scanning force microscopy micrographs show that the mechanism of volume phase transition on soft surfaces cannot be directly deduced from the processes taking place at solid substrates.

Graphical abstract: Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Feb 2015, accepted on 09 Apr 2015 and first published on 14 Apr 2015


Article type: Paper
DOI: 10.1039/C5CP01213A
Author version
available:
Download author version (PDF)
Phys. Chem. Chem. Phys., 2015,17, 12771-12777

  •   Request permissions

    Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

    A. S. Vikulina, S. T. Aleed, T. Paulraj, Yu. A. Vladimirov, C. Duschl, R. von Klitzing and D. Volodkin, Phys. Chem. Chem. Phys., 2015, 17, 12771
    DOI: 10.1039/C5CP01213A

Search articles by author

Spotlight

Advertisements