Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective
Enzyme-catalysed H-transfer reactions are ubiquitous, yet fundamental details of these reactions remain unresolved. In this perspective, we discuss the roles of nuclear quantum tunnelling and (compressive) dynamics during these reactions. Evidence for the coupling of specific substrate and/or protein vibrations to the chemical coordinate is considered and a case is made for the combination of multiple experimental and computational/theoretical approaches when studying these reactions.
- This article is part of the themed collection: Measurement and prediction of quantum coherence effects in biological processes