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Issue 46, 2015
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Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

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Abstract

Enzyme-catalysed H-transfer reactions are ubiquitous, yet fundamental details of these reactions remain unresolved. In this perspective, we discuss the roles of nuclear quantum tunnelling and (compressive) dynamics during these reactions. Evidence for the coupling of specific substrate and/or protein vibrations to the chemical coordinate is considered and a case is made for the combination of multiple experimental and computational/theoretical approaches when studying these reactions.

Graphical abstract: Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

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Publication details

The article was received on 30 Jan 2015, accepted on 27 Mar 2015 and first published on 27 Mar 2015


Article type: Perspective
DOI: 10.1039/C5CP00614G
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Phys. Chem. Chem. Phys., 2015,17, 30775-30782
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    Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

    L. O. Johannissen, S. Hay and N. S. Scrutton, Phys. Chem. Chem. Phys., 2015, 17, 30775
    DOI: 10.1039/C5CP00614G

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