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Issue 46, 2015
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Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

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Abstract

Enzyme-catalysed H-transfer reactions are ubiquitous, yet fundamental details of these reactions remain unresolved. In this perspective, we discuss the roles of nuclear quantum tunnelling and (compressive) dynamics during these reactions. Evidence for the coupling of specific substrate and/or protein vibrations to the chemical coordinate is considered and a case is made for the combination of multiple experimental and computational/theoretical approaches when studying these reactions.

Graphical abstract: Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

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Article information


Submitted
30 Jan 2015
Accepted
27 Mar 2015
First published
27 Mar 2015

This article is Open Access

Phys. Chem. Chem. Phys., 2015,17, 30775-30782
Article type
Perspective
Author version available

Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

L. O. Johannissen, S. Hay and N. S. Scrutton, Phys. Chem. Chem. Phys., 2015, 17, 30775
DOI: 10.1039/C5CP00614G

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