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Issue 77, 2015
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Biomimetic synthesis of Tramadol

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Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product–precursor relationship has been probed by 13C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.

Graphical abstract: Biomimetic synthesis of Tramadol

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17 Jul 2015
05 Aug 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 14451-14453
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Author version available

Biomimetic synthesis of Tramadol

F. Lecerf-Schmidt, R. Haudecoeur, B. Peres, M. M. Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J. Wolfender, M. De Waard, R. J. Robins and A. Boumendjel, Chem. Commun., 2015, 51, 14451
DOI: 10.1039/C5CC05948H

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