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Issue 74, 2015
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A luminescent ruthenium(ii) complex for light-triggered drug release and live cell imaging

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Abstract

We report a novel ruthenium(II) complex for selective release of the imidazole-based drug econazole. While the complex is highly stable and luminescent in the dark, irradiation with green light induces release of one of the econazole ligands, which is accompanied by a turn-off luminescence response and up to a 34-fold increase in cytotoxicity towards tumour cells.

Graphical abstract: A luminescent ruthenium(ii) complex for light-triggered drug release and live cell imaging

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Supplementary files

Article information


Submitted
25 Jun 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14038-14041
Article type
Communication
Author version available

A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging

N. Karaoun and A. K. Renfrew, Chem. Commun., 2015, 51, 14038
DOI: 10.1039/C5CC05172J

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