In this communication, using sub-picosecond resolved fluorescence upconversion spectroscopy, we discover that despite a large fluorescence enhancement observed for thioflavin-T in insulin fibrils, the majority of fibril bound thioflavin-T undergoes efficient ultrafast conformational relaxation, and thus does not contribute to the characteristic fluorescence enhancement.
P. K. Singh, A. K. Mora and S. Nath, Chem. Commun., 2015, 51, 14042 DOI: 10.1039/C5CC04256A
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