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Issue 97, 2015
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Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide–alkyne cycloadditions

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Abstract

The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide–alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 ± 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in ≥80% enantiomeric excess (e.e.).

Graphical abstract: Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide–alkyne cycloadditions

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Supplementary files

Article information


Submitted
12 Jun 2015
Accepted
12 Aug 2015
First published
27 Aug 2015

This article is Open Access

Chem. Commun., 2015,51, 17217-17220
Article type
Communication
Author version available

Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide–alkyne cycloadditions

W. D. G. Brittain, B. R. Buckley and J. S. Fossey, Chem. Commun., 2015, 51, 17217
DOI: 10.1039/C5CC04886A

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