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Issue 97, 2015
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Exploring water as building bricks in enzyme engineering

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Abstract

A novel enzyme engineering strategy for accelerated catalysis based on redesigning a water network through protein backbone deshielding is presented. Fundamental insight into the energetic consequences associated with the design is discussed in the light of experimental results and computer simulations. Using water as biobricks provides unique opportunities when transition state stabilisation is not easily attained by traditional enzyme engineering.

Graphical abstract: Exploring water as building bricks in enzyme engineering

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Publication details

The article was received on 25 Aug 2015, accepted on 23 Sep 2015 and first published on 25 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC07162C
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Citation: Chem. Commun., 2015,51, 17221-17224
  • Open access: Creative Commons BY-NC license
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    Exploring water as building bricks in enzyme engineering

    P. Hendil-Forssell, M. Martinelle and P. Syrén, Chem. Commun., 2015, 51, 17221
    DOI: 10.1039/C5CC07162C

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