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Issue 67, 2015
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Insight into the esterase like activity demonstrated by an imidazole appended self-assembling hydrogelator

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Abstract

A low molecular weight hydrogelator with a covalently appended imidazole moiety is reported. Capable of percolating water in the pH range of 6 to 8, it proves to be an efficient catalyst upon self-assembly, showing Michaelis–Menten type kinetics. Activities at different pH values correlated with dramatic structural changes were observed. It can hydrolyse p-nitrophenyl acetate (pNPA) as well as inactivated esters, and L and D-phenylalanine methyl esters. The enhanced activity can be related to the conglomeration of catalytic groups upon aggregation resulting in their close proximity and the formation of hydrophobic pockets.

Graphical abstract: Insight into the esterase like activity demonstrated by an imidazole appended self-assembling hydrogelator

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Supplementary files

Article information


Submitted
25 May 2015
Accepted
09 Jul 2015
First published
10 Jul 2015

This article is Open Access

Chem. Commun., 2015,51, 13213-13216
Article type
Communication
Author version available

Insight into the esterase like activity demonstrated by an imidazole appended self-assembling hydrogelator

N. Singh, M. P. Conte, R. V. Ulijn, J. F. Miravet and B. Escuder, Chem. Commun., 2015, 51, 13213
DOI: 10.1039/C5CC04281J

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