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Issue 31, 2015
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Facile fabrication of microsphere-polymer brush hierarchically three-dimensional (3D) substrates for immunoassays

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Abstract

We propose a facile UV strategy to construct a hierarchically three-dimensional (3D) substrate that comprises a polystyrene (PS) microsphere layer on the cycloolefin polymer (COP) substrate and densely packed hydrophilic polymer brushes grafting from this 3D backbone. This hierarchical substrate gives a high antibody loading capacity and 3D manner of analyte capture, therefore enhancing detection signal while reducing background noise.

Graphical abstract: Facile fabrication of microsphere-polymer brush hierarchically three-dimensional (3D) substrates for immunoassays

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Publication details

The article was received on 10 Feb 2015, accepted on 12 Mar 2015 and first published on 12 Mar 2015


Article type: Communication
DOI: 10.1039/C5CC01250C
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Chem. Commun., 2015,51, 6749-6752

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    Facile fabrication of microsphere-polymer brush hierarchically three-dimensional (3D) substrates for immunoassays

    J. Ma, S. Luan, L. Song, S. Yuan, S. Yan, J. Jin and J. Yin, Chem. Commun., 2015, 51, 6749
    DOI: 10.1039/C5CC01250C

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