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Issue 27, 2015
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A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

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Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.

Graphical abstract: A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

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Supplementary files

Article information


Submitted
09 Feb 2015
Accepted
21 Feb 2015
First published
26 Feb 2015

This article is Open Access

Chem. Commun., 2015,51, 6018-6021
Article type
Communication
Author version available

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen, J. A. Frank, N. R. Johnston, R. K. Mitchell, K. Šmid, P. Marchetti, M. Bugliani, G. A. Rutter, D. Trauner and D. J. Hodson, Chem. Commun., 2015, 51, 6018
DOI: 10.1039/C5CC01224D

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