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Issue 24, 2015
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Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

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Abstract

An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.

Graphical abstract: Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

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The article was received on 06 Jan 2015, accepted on 14 Feb 2015 and first published on 19 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00085H
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Chem. Commun., 2015,51, 5100-5103

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    Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

    P. L. van der Peet, C. Gunawan, S. Torigoe, S. Yamasaki and S. J. Williams, Chem. Commun., 2015, 51, 5100
    DOI: 10.1039/C5CC00085H

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