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Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey and E. Tomat, Chem. Commun., 2015, 51, 5104 DOI: 10.1039/C5CC00829H
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