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Issue 26, 2015
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Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers

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Abstract

Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.

Graphical abstract: Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers

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Publication details

The article was received on 05 Jan 2015, accepted on 10 Feb 2015 and first published on 10 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00082C
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Chem. Commun., 2015,51, 5747-5750

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    Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers

    R. E. Kohman and X. Han, Chem. Commun., 2015, 51, 5747
    DOI: 10.1039/C5CC00082C

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