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Issue 29, 2016
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Biofunctionalization of polydioxythiophene derivatives for biomedical applications

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Abstract

The polydioxythiophenes PEDOT and more recently ProDOT have emerged as champion materials in the field of organic bioelectronics, both in the domain of biosensing and also for integration with living cells (both in vitro and in vivo). Although polydioxythiophenes in their pristine forms have shown great promise for bioelectronics, in order to broaden the spectrum of applications, a biofunctionalization step is essential. In this review we summarise the methods that have been used thus far to biofunctionalize polydioxythiophenes in an effort to improve the biotic/abiotic interface. We provide an introduction to this class of materials, focusing particularly on the different methods of synthesis (chemical oxidative polymerization, vapor phase polymerization or direct electrochemical polymerization) and discuss the implications of synthesis on biofunctionalization. Rather than provide an exhaustive review, we chose to highlight key examples of biofunctionalization techniques for polydioxythiophenes for specific biomedical applications. Finally, we conclude with a brief discussion of the importance of biofunctionalization methods in future bioelectronics applications, and some ideas for future directions in this field.

Graphical abstract: Biofunctionalization of polydioxythiophene derivatives for biomedical applications

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Article information


Submitted
06 Apr 2016
Accepted
16 Jun 2016
First published
16 Jun 2016

This article is Open Access

J. Mater. Chem. B, 2016,4, 4952-4968
Article type
Review Article
Author version available

Biofunctionalization of polydioxythiophene derivatives for biomedical applications

X. Strakosas, B. Wei, D. C. Martin and R. M. Owens, J. Mater. Chem. B, 2016, 4, 4952
DOI: 10.1039/C6TB00852F

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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