Issue 29, 2016

Biofunctionalization of polydioxythiophene derivatives for biomedical applications


The polydioxythiophenes PEDOT and more recently ProDOT have emerged as champion materials in the field of organic bioelectronics, both in the domain of biosensing and also for integration with living cells (both in vitro and in vivo). Although polydioxythiophenes in their pristine forms have shown great promise for bioelectronics, in order to broaden the spectrum of applications, a biofunctionalization step is essential. In this review we summarise the methods that have been used thus far to biofunctionalize polydioxythiophenes in an effort to improve the biotic/abiotic interface. We provide an introduction to this class of materials, focusing particularly on the different methods of synthesis (chemical oxidative polymerization, vapor phase polymerization or direct electrochemical polymerization) and discuss the implications of synthesis on biofunctionalization. Rather than provide an exhaustive review, we chose to highlight key examples of biofunctionalization techniques for polydioxythiophenes for specific biomedical applications. Finally, we conclude with a brief discussion of the importance of biofunctionalization methods in future bioelectronics applications, and some ideas for future directions in this field.

Graphical abstract: Biofunctionalization of polydioxythiophene derivatives for biomedical applications

Article information

Article type
Review Article
06 Apr 2016
16 Jun 2016
First published
16 Jun 2016
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2016,4, 4952-4968

Author version available

Biofunctionalization of polydioxythiophene derivatives for biomedical applications

X. Strakosas, B. Wei, D. C. Martin and R. M. Owens, J. Mater. Chem. B, 2016, 4, 4952 DOI: 10.1039/C6TB00852F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity