Issue 7, 2015

Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by N-heterocyclic carbene at atmospheric pressure

Abstract

Under atmospheric pressure, quinazoline-2,4(1H,3H)-diones were obtained from the reaction of 2-aminobenzonitriles with carbon dioxide (0.1 MPa) with a catalytic amount of N-heterocyclic carbene in DMSO. It was found that various electron-donating and electron-withdrawing groups such as –OMe, –F, –Cl, –Br, –CH3, –CF3 and –CN were well tolerated to give the products in almost quantitative yields.

Graphical abstract: Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by N-heterocyclic carbene at atmospheric pressure

Article information

Article type
Paper
Submitted
04 Nov 2014
Accepted
11 Dec 2014
First published
11 Dec 2014

RSC Adv., 2015,5, 5032-5037

Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 catalyzed by N-heterocyclic carbene at atmospheric pressure

Y. Xiao, X. Kong, Z. Xu, C. Cao, G. Pang and Y. Shi, RSC Adv., 2015, 5, 5032 DOI: 10.1039/C4RA13752C

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